Healing of Osteochondral Defects via Endochondral Ossification in an Ovine Model
نویسندگان
چکیده
منابع مشابه
Engineering osteochondral constructs through spatial regulation of endochondral ossification.
Chondrogenically primed bone marrow-derived mesenchymal stem cells (MSCs) have been shown to become hypertrophic and undergo endochondral ossification when implanted in vivo. Modulating this endochondral phenotype may be an attractive approach to engineering the osseous phase of an osteochondral implant. The objective of this study was to engineer an osteochondral tissue by promoting endochondr...
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Perilesional changes of chronic focal osteochondral defects were assessed in the knees of 23 sheep. An osteochondral defect was created in the main load-bearing region of the medial condyle of the knees in a controlled, standardised manner. The perilesional cartilage was evaluated macroscopically and biopsies were taken at the time of production of the defect (T0), during a second operation one...
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ژورنال
عنوان ژورنال: CARTILAGE
سال: 2017
ISSN: 1947-6035,1947-6043
DOI: 10.1177/1947603517713818